Formation and properties of biocompatible Ti-based bulk metallic glasses in the Ti–Cu–Zr–Fe–Sn–Si–Ag system

The Ni-free Ti-based bulk metallic glasses (BMGs) with high glass-forming ability (GFA) can be synthesized in the (Ti, Cu, Zr)92.5Fe2.5Sn2Si1Ag2 alloy system over a wide composition range by copper-mold casting. Especially, Ti48Cu37Zr7.5Fe2.5Sn2Si1Ag2 glassy form BMG rod diameter up to 6 mm and showed compressive strength of ~ 2.05 GPa, elastic modulus 100 microhardness 571 Hv. BMGs presented good bio-corrosion resistance simulated physiological environment attributed formation Ti-, Zr-, Si-, Fe-enriched passive films. biocompatibility alloys was systematically investigated both indirect cytotoxicity test direct cell-culture experiments. extracts had no cytotoxic effects on proliferation cells. cell adhesion, proliferation, differentiation, mineralization bone-forming MC3T3-E1 pre-osteoblasts were parallel those Ti–6Al–4V alloy. These results manifested that present are promising candidates as biomaterials.